HYPERONCOTIC ARTIFICIAL CEREBROSPINAL FLUID AND METHOD OF TREATING NEURAL TISSUE EDEMA THEREWITH.

• 1. 分布式处理用人工神经网络运算加速装置、利用其的人工神经网络加速系统、及该人工神经网络的加速方法 [P] . 中国专利： CN112805727A . 2021-05-14
• 2. 人工神经网络和利用表观遗传神经发生训练人工神经网络的方法 [P] . 中国专利： CN112912902A . 2021-06-04
• 3. Hyperoncotic artificial cerebrospinal fluid and method of treating neural tissue edema therewith [P] . 美国专利： US6500809B1 . 2002-12-31

  机译： 高渗人工脑脊液及其治疗神经组织水肿的方法

• 4. HYPERONCOTIC ARTIFICIAL CEREBROSPINAL FLUID AND METHOD OF TREATING NEURAL TISSUE EDEMA THEREWITH [P] . 世界知识产权组织专利： WO0134225A3 . 2002-07-11

  机译： 高渗人工脑脊髓液及其治疗神经组织水肿的方法

• 5. HYPERONCOTIC ARTIFICIAL CEREBROSPINAL FLUID AND METHOD OF TREATING NEURAL TISSUE EDEMA THEREWITH [P] . 欧洲知识产权局专利： EP1235593A2 . 2002-09-04

  机译： 高渗人工脑脊髓液及其治疗神经组织水肿的方法

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• 2. Simulation and Off-line Optimization of an Acrylonitrile Fluidized-bed Reactor Based on Artificial Neural Network [J] . 李伟, 张述伟, 李燕, 中国化学工程学报（英文版） . 2002,第002期
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• 4. Non-invasive Assessment of Cerebrospinal Fluid and Brain Tissue Biomechanics Using MRI and Computational Modeling [D] . Heidari Pahlavian, Soroush. 2018
• 5. The Effect of Reductive Ventricular Osmotherapy on the Osmolarity of Artificial Cerebrospinal Fluid and the Water Content of Cerebral Tissue Ex Vivo [O] . Rick M. Odland, S. Scott Panter, Gaylan L. Rockswold -1
• 6. The Effect of Reductive Ventricular Osmotherapy on the Osmolarity of Artificial Cerebrospinal Fluid and the Water Content of Cerebral Tissue Ex Vivo [O] . Odland, Rick M., Panter, S. Scott, Rockswold, Gaylan L. 2011

• 1. BACKGROUND： Vibrio vulnifi cus inside the body could activate the NF-!B signaling pathwayand initiate the inflammatory cascade. The lung is one of the earliest organs affected by sepsisassociated with acute lung injury. High mobility group protein B1 （HMGB1） is an important late-actingpro-infl ammatory cytokine involving in the pathophysiology of sepsis. It is also involved in the injuryprocess in the lung, liver and intestine. There has been no report on the involvement of HMGB1 inVibrio vulnifi cus sepsis-induced lung injury.METHODS： Sixty rats were randomly divided into a normal control group （group A, n=10） anda Vibrio vulnificus sepsis group （group B, n=50）. Sepsis was induced in the rats by subcutaneousinjection of Vibrio vulnificus （concentration 6×108 cfu/mL, volume 0.1 mL/100g）） into the left lowerlimbs. The rats in group B were sacrifi ced separately 1, 6, 12, 24, and 48 hours after the infection.Their lungs were stored as specimens, lung water content was measured, and lung pathology wasobserved under a light microscope. The expressions of the HMGB1 gene and protein in the lungswere detected by RT-PCR and Western blot. Data were analyzed with one-way analysis of variance（ANOVA） and the LSD method for pair-wise comparison between the two groups. P〈0.05 wasconsidered statistically signifi cant.RESULTS： Compared to group A （0.652±0.177）, HMGB1 mRNA expression in the lungs ofgroup B was signifi cantly higher at 0 hour （1.161±0.358, P=0.013）, 24 hours （1.679±0.235, P=0.000）,and 48 hours （1.258±0.274, P=0.004） （P〈0.05）, and peaked at 24 hours. Compared to group A（0.594±0.190）, HMGB1 protein expression at 6 hours （1.408±0.567, P=0.026） after infection wassignificantly increased （P〈0. 05）, and peaked at 24 hours （2.415±1.064, P=0.000） after infection.Compared to group A （0.699±0.054）, lung water content was significantly increased at 6 hours（0.759±0.030, P=0.001）,12 hours （0.767±0.023, P=0.000）, 24 hours （0.771±0.043, P=0.000） and 48hours （0.789±0.137, P=0.000） after infection （P〈0.05）. Compared to group A, pathological changesat 12 hours in group B indicate marked pulmonary vascular congestion, interstitial edema andinfl ammatory infi ltration. Alveolar cavity collapse and boundaries of the alveolar septum could not beclearly identifi ed.CONCLUSION： Vibrio vulnifi cus sepsis can lead to injury in rat lungs, and increased HMGB1expression in lung tissue may be one of the mechanisms for injury from Vibrio vulnifi cus sepsis. [J] . Qiao-meng Qiu ,Zhong-wang Li ,Lu-ming Tang . 世界急诊医学杂志(英文) . 2011,第4期
• 2. Clinical Status of Patients with Cerebrospinal Fluid Hypovolemia Treated with an Epidural Blood Patch [J] . Takafumi Nishizaki ,Norio Ikeda ,Shigeki Nakano . 现代神经外科学进展（英文） . 2015,第4期
• 3. Treating Ventricular Hemorrhage by Bilateral External Ventricular Drainage, Perfusion with Urokinase, Lumbar Puncture and Replacement of Cerebrospinal Fluid--Attached Report on 16 Cases [J] . GUI ,Yaxiong ,CHEN . 美国中华健康卫生杂志 . 2005,第004期
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