PEG-based macromonomers with oxetane end groups and chemically inert polymers prepared therefrom and the use of these polymers for support in organic synthesis and enzyme reactions

摘要

Macromonomers containing ethylene glycol repeat units, to chemically inert polymers prepared therefrom and to the use of such polymers in solid phase biochemical assays is disclosed. Particularly disclosed is a macromonomer of polyethylene glycol having repeat units in the range 6-300 and having at least one end terminated by an ether group having formula (I) where m is an integer of 0-10, a is an integer of 1-4, and R is H or alkyl or aryl or arylalkyl; or having formula (II) where m is an integer of 1-10, and R is H or alkyl or aryl or arylalkyl.