Procedure for bicycle derivatives to be replaced to deal with abnormal cell growth

摘要

REFERS TO A PROCEDURE FOR PREPARING SUBSTITUTED BICYCLE COMPOUNDS OF FORMULA I WHERE, m ES 0-3, p ES 0-4, R1 AND R2 ARE H, ALKYL, R3 IS C (R1R) t-HETEROCICLO CONDENSED TO A BENZENE, CYCLLOALKYL; t IS 0-5; R4 ES C @ C (R16R17) tR9; C = C (R16R17) tR9, C @ C (R16R17) kR13; C = C (R16R17) kR13; R5 IS HALO, HYDROXY, NR1R2, ALKYL, TRIFLUOROMETHYL, ALCOXI, TRIFLUOROMETOXI, NR6COR1, CONR6R7, AMONG OTHERS; R6, R7 ARE H, ALKYL, (CR1R2) TARIL, (CR1R2) tHETEROCICLICO. THEY ARE PREFERRED COMPOUNDS (+/-) - [3-METHYL-4- (PIRIDIN-3-ILOXI) -PHENYL] - (6-PIPERIDIN-3-ILETINYL-QUINAZOLIN-4-IL) -AMINE; 2-METOXI-N- (3- {4- [3-METHYL-4- (PIRIDIN-3-ILOXI) -PHENYLAMINE] -QUINAZOLIN-6-IL} -PROP-2-INIL) ACETAMIDE;(+ /) - [3-methyl-4 - (6-methyl-pyridine-3-aldrin-aldrin-phenyl) - phenyl] - (6-pyridin-3-illegal-quinine-4-il) - ammonia water, including, inter Alia, m-c-formula compound - (cr16r17) t-r9; m is h, B (R19) 2, Al (R20) 2, Sn (R21) 3, MGW, ZNW; R19, alculo, alcoxi, cyclo, etc. Compound I may help to treat abnormal growth as a carcinogen