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Bloodless distribution of pharmacists and pharmacists with lipid microphase

机译:药剂师和具有脂质微相的药剂师的无血分布

摘要

It includes: (a) a solid-state diffusion consisting of a low solubility Pharmacopoeia and a polymer to increase the concentration; and (b) a material to form the selected lipid microphase:The medium chain of DI and tri carat diethylene glycol, shuobitan mat, etc., with a large-scale supply of 0.1 to 100 in the pharmacists described; in sufficient quantities, synthesis can improve the concentration of pharmacists in the use environment to control and / or Second control unit Wherein: (1) the first control component is composed of a considerable number of (a) non (b);(2) the second control component is composed of the same amount of low solubility Pharmacopoeia, and its non dispersive form is the same as the same amount of (b) but no polymer, increasing the concentration; In (b) water insoluble and low soluble Pharmacopoeia, the above-mentioned use environment and (b) KP partition coefficient of at least 0.02% by weight / second, while the maximum water solubility of such low soluble pharmacopoeia is 0.02% by weight. It also refers to the procedures for joint management of (a) and (b).
机译:它包括:(a)由低溶解度药典和增加浓度的聚合物组成的固态扩散; (b)形成所选脂质微相的材料:DI和三克拉二甘醇,硕必坦垫等的中链,所述药剂师的批量供应量为0.1至100;在足够的数量下,合成可以提高使用环境中控制和/或第二控制单元的药剂师的浓度,其中:(1)第一控制成分由相当数量的(a)非(b)组成;(2)第二控制组分由等量的低溶解度药典组成,其非分散形式与等量的(b)相同,但没有聚合物,增加了浓度。在(b)水不溶性和低可溶性药典中,上述使用环境和(b)KP分配系数至少为0.02重量%/秒,而这种低可溶性药典的最大水溶性为0.02重量%。它还指(a)和(b)的联合管理程序。

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