Compounds 4 - carboxiamino - 2 - substituted - 1,2,3,4 - Tetrahidroquinolina pharmacist; Pharmaceutical composition; kit; and use of the compounds as inhibitors of the Colesteril ester transfer protein (CETP) in the treatment of aterosclerosIs, Peripheral Vascular Disease, dyslipidemia, hypertriglyceridemia.

摘要

Inhibitors of Protein Transfer Colesteril Ester Derivative, consisting of 4 - carboxiamino replaced - 2 - substituted - 1,2,3,4 tetrahydro - quinolinas formula I.Pharmaceutical compositions and Kits containing them and its use to raise levels of plasma Lipids, including cholesterol bound to high density lipoptrteinas,And to reduce certain levels of plasma Lipids, such as cholesterol and LDL and triglycerides and, accordingly,To treat diseases that are axacerban by low levels of HDL cholesterol and / or high levels of LDL cholesterol and triglycerides.And cardiovascular diseases such as atherosclerosis, dyslipidemia, hypertriglyceridemia in Mammals, including humans.