THE USE OF DES-ASPARTATE-ANGIOTENSIN I AS AN AGENT FOR THE TREATMENT AND PREVENTION OF NEOINTIMA FORMATION, RESTENOSIS, AND ARTERIOSCLEROSIS

摘要

The use of des-Aspartate-angiotensin I (Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu) as ananti-neointima and anti-arteriosclerotic agent was described. The compound, givenintravenously attenuates the development of neointima formation in balloon catheter-injured carotid arteries of Sprague Dawley rats. The anti-neointima action was dose-dependent and the maximum effect was obtained with a dose of 10 pmoles per daygiven 2 days pre- and 13 days post-balloon catheterization. When given orally on achronic basis at a dose of 0.9 mg/kg/day for 47 weeks, the compound significantlyattenuates the development of arteriosclerosis in the spontaneously hypertensive rats.The anti-arteriosclerotic action was not blood pressure dependent.