SCREENING METHODS TO IDENTIFY COMPOUNDS THAT MODULATE A RESPONSE OF A CELL TO ULTRAVIOLET RADIATION EXPOSURE

摘要

Title: SCREENING METHODS TO IDENTIFY COMPOUNDS THAT MODULATE A RESPONSE OF A CELL TO UL-TRAVIOLET RADIATION EXPOSUREAbstract: The cellular response to ultraviolet radiation exposure has been characterized on the molecular level through the use of high density gene array technology. Nucleic acid molecules and protein molecules, the expression of which are repressed or induced in response to ultraviolet radiation exposure, are identified according to a temporal pattern of altered expression post ultraviolet radiation exposure. Methods are disclosed that utilized these ultraviolet radiation-regulated molecules as markers forultraviolet radiation exposure. Other screening methods of the invention are designed for the idenfication of compounds that mod-ulate the response of a cell to ultraviolet radiation exposure. The invention also provides compositions useful for drug screening or pharmaceutical purposes.