UPA UNION SITES IN THE 2 + 3 DOMAIN OF UPAR AND REACTIVE ANTIBODIES WITH THE SAME.

摘要

THE INVENTION REFERS TO AN ANTIBODY THAT INHIBITS THE UNION BETWEEN U-PA AND U-PAR UP TO A PERCENTAGE OF 90% AT A MINIMUM IN A TEST AS DEFINED IN THE SPECIFICATION, OR AN ACTIVE OR EQUIVALENT IMMUNOLOGICAL FRAGMENT OF SUCH ANTIBODY. SAMPLES OF THE CITED ANTIBODIES HAVE BEEN DEPOSITED ON JULY 7 IN THE DEUTSCHE SAMMLUNG VON MIKROORGANISMEN UND ZELLKULTUREN (DSM) WITH THE REFERENCE NUMBERS DSM ACC2178 AND DSM ACC2179 UNDER THE TERMS AND CONDITIONS ESTABLISHED IN THE BUDGET. THE INVENTION REFERS IN ADDITION TO A METHOD FOR DETECTING OR QUANTIFYING U-PAR OR A U-PAR GLUCOSILATION VARIANT IN A SAMPLE, BY USING AN ANTIBODY ACCORDING TO THE INVENTION. IN ADDITION, THE INVENTION REFERS TO A METHOD FOR THE MANUFACTURE OF A THERAPEUTIC AGENT TO PREVENT OR CONTRAREST THE PROTEOLITICAL ACTIVITY USING THE ANTIBODY OF THE INVENTION, AS WELL AS THE USE OF AN ANTIBODY ACCORDING TO THE INVENTION FOR THE PREPARATION OF A DIAGNOS AGENT TO DETERMINE THE DIAGNOSIS OF A CELL THAT CONTAINS U-PAR ON THE SURFACE.