NOVEL OVEREXPRESSED PROTEIN IN PROSTATE CANCER

摘要

The invention relates to a novel overexpressed gene and protein in prostate cancer that has been identified and sequenced and the invention demonstrates that said protein is overexpressed in prostate adenocarcinoma using the western-blot and RT-PCR technique. The expression of said protein is correlated with the proliferation of tumours. Specific antibodies have been generated that specifically detect the protein both in cell lines and in human normal and tumour tissue using immunological methods. Using said antibodies, the invention demonstrates that the protein is overexpressed in the majority of human prostate adenocarcinomas and, therefore, the detection of said transcript and protein constitutes a novel marker for this type of tumour, with potential use in the diagnosis thereof. Furthermore, said protein is a target protein. The invention also relates to the identification of compounds for antitumour therapies.