INVESTED HYDROXAMATE COMPOUNDS AS INHIBITORS OF MARRIAGE METALOPROTEASES.

摘要

A compound of the ** formula ** or a pharmaceutically acceptable salt or prodrug thereof, wherein W1 is selected from the group consisting of (1) -O-, (2) -CH2O-, and (3) -CH2-; where each group is such that its left end is the end that binds to the carbon containing R1 and R2, and its right end is the end that joins the carbon that contains R3 and R4; X is selected from the group consisting of (1) -O-, (2) -N (R7), where R7 is selected from the group consisting of (a) hydrogen, (b) alkyl, (c) -SO2-alkyl , and (d) alkanoyl; R1 and R2 are independently selected from the group consisting of (1) hydrogen, (2) alkyl, and (3) hydroxyalkyl; R3 and R4 are independently selected from the group consisting of (1) hydrogen, and (2) alkyl, or R3 and R4 taken together are oxo, or R3 and R4, taken together with the carbon atom to which they are attached, they form a cycloalkyl ring; R5 and R6 are independently selected from the group consisting of (1) hydrogen, (2) alkyl, (3) perfluoroalkyl, (4) halo, (5) haloalkyl, (6) alkoxy, (7) hydroxy, (8) hydroxyalkyl , (9) alkoxyalkyl, and (10) nitro; Y1 is selected from the group consisting of (1) (2) (3) (4) (5) (6) (7) (8) a covalent bond -O-, alkylene of two to four carbon atoms, piperidinoneyl, two-carbon alkenylene, two-carbon alkynylene, -SO2-, and -C (O) -