INHIBITION OF MAMMALIAN MUSCLE WASTING AND PROTEIN DEGRADATION BY TETRACYCLINES

摘要

A method for treating mammals suffering fromskeletal muscle wasting and/or intracellular proteindegradation of skeletal muscle systems by administering tothe mammal an amount of tetracycline which results in asignificant reduction of the muscle wasting and proteindegradation is disclosed. In addition, there is alsodisclosed a method of increasing the protein content ofskeletal muscle systems of mammals by administration oftetracyclines. The tetracyclines useful in the abovemethods are both antimicrobial and non-antimicrobial. Ina preferred embodiment, the method of treatment utilizes anon-antimicrobial tetracycline such as dedimethylamino-tetracycline (CMT).