OLIGONUCLEOTIDES FOR MODULATING THE EFFECTS OF CYTOMEGALOVIRUS INFECTIONS

摘要

Compositions and methods for modulating the effects of cytomegalovirus (CMV)infections are disclosed, comprising con-tacting CMV mRNA with an oligonucleotide or oligonucleotide analog which canbind with at least portions of the CMV RNA.In accordance with the preferred embodiments, oligonucleotides oroligonucleotide analogs are designed to bind with portions ofthe CMV mRNAs which code for the IE1, IE2 or DNA polymerase proteins. Inaccordance with a preferred embodiment, meth-ods of treatment of human cytomegalovirus are disclosed.