.ALPHA.AED AND .BETA.AED REGULATION OF NUCLEAR TRANSCRIPTION, GENE REGULATION, AND/OR GENE EXPRESSION

摘要

The present invention provides a means to regulate nuclear transcriptionand/or gene expression. The present invention also provides a means toregulate the levels of PPAR-.gamma., COX-2 and/or NF.kappa.B in a patient. Themethod of the present invention involves administering .alpha.AED (or ananalogue thereof) or .beta.AED (or an analogue thereof) or both to a patientin need of regulation of nuclear transcription and/or gene expression and/orlevels of PPAR-.gamma., COX-2, and/or NF.kappa.B. The methods of the presentinvention can be used to control adipogenesis (i.e. to treat obesity),angiogenesis, atherosclerosis, mesenteric fat hypertrophy, inflammatory boweldisease, colitis, Alzheimer's disease, and inflammatory glial responses in thebrain. The methods of the present invention can also be used for treatingdiabetes, for regulating the immune response, and for regulating inflammationin a patient.