alphaAED AND betaAED REGULATION OF NUCLEAR TRANSCRIPTION, GENE REGULATION, AND/OR GENE EXPRESSION

摘要

The present invention provides a means to regulate nuclear transcription and/or gene expression. The present invention also provides a means to regulate the levels of PPAR-gamma, COX-2 and/or NFkappaB in a patient. The method of the present invention involves administering alphaAED (or an analogue thereof) or betaAED (or an analogue thereof) or both to a patient in need of regulation of nuclear transcription and/or gene expression and/or levels of PPAR-gamma, COX-2, and/or NFkappaB. The methods of the present invention can be used to control adipogenesis (i.e. to treat obesity), angiogenesis, atherosclerosis, mesenteric fat hypertrophy, inflammatory bowel disease, colitis, Alzheimer's disease, and inflammatory glial responses in the brain. The methods of the present invention can also be used for treating diabetes, for regulating the immune response, and for regulating inflammation in a patient.