USE OF HUMAN NEURAL STEM CELLS SECRETING GDNF FOR TREATMENT OF PARKINSON'S AND OTHER NEURODEGENERATIVE DISEASES

摘要

A method of treating brain disorders involving loss of cells that respond toGDNF is disclosed. In one embodiment, the invention comprises the steps of (a)transducing human neural stem cells with glial-derived neurotrophic factor(GDNF), wherein the GDNF gene is under control of an inducible promotersystem, and (b) transplanting the transduced cells into the brain of a patient.