BAGE GENES, PROTEINS CODED BY THE SAME, AND THEIR USES FOR THE TREATMENT OR THE DIAGNOSIS OF MELANOMAS

摘要

The invention relates to new BAGE genes, tumor antigen proteins encoded by the same, or derived proteins, or fragments thereof, said proteins of the BAGE family comprising the following SEQ ID NO: 1 sequence: MAAGX1VFLALSAQLLQARLMKEESPVVSWX2LEPEDGTALX3[X4X5F]n in which n represents 0 or 1, X1 represents V or A, V2 represents R or W, X3 represents Z, D or C, X4 represents V or F, X5 represents H or I. The invention also relates the uses of said proteins or corresponding nucleotide sequences for the treatment or the diagnosis of pathologies wherein fragments of said tumor antigens are expressed at the cell surface, such as melanomas.