Iterative promoter affinity chromatography to identify trans-regulatory networks of gene expression

摘要

The present invention is directed to novel proteomic and genomic technologies based on iterative promoter affinity chromatography (IPAC) and a reverse translation algorithm permutation analysis of genomic sequences (PANGSEQ). These technologies permit the development of trans-regulatory networks for the predictive modeling of complex biological systems and are relevant to drug discovery as well as diagnostic and research applications in the field of organogenesis and pathogenesis.