SYNTHESIS OF IMPERANENE DERIVATIVES FROM HYDROXYMATAIRESINOL

摘要

This invention concerns a method for the preparation of imperanene from hydroxymatairesinol. In a first step hydroxymatairesinol is converted to 4-(4-hydroxy-3-methoxyphenyl)-2-(4-hydroxy-3-methoxyphenylmethyl)-but-3-enoic acid. This acid is then preferably esterified by use of an alcohol R-OH, wherein R is an alkyl or aryl group, to an ester (III), which is reduced to imperanene.The invention concerns also the use of esters (III) as intermediates in the synthesis of imperanene and novel esters of formula (III).