CRYSTALS STRUCTURE OF THE MOUSE APOPTOSIS-INDUCING FACTOR AIF AND APPLICATIONS THEREOF

摘要

Structural features of Apoptosis-inducing Factor (AIF), a flavoprotein that can stimulate a caspase-independent cell-death pathway. Structure-based screening, identification and design of molecules that modulate AIF functional activities, including apoptosis and redox activity. Molecules useful for modulating apoptosis or AIF redox activity obtained by these methods.