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GENOMICS-DRIVEN HIGH SPEED CELLULAR ASSAYS, DEVELOPMENT THEREOF, AND COLLECTIONS OF CELLULAR REPORTERS
GENOMICS-DRIVEN HIGH SPEED CELLULAR ASSAYS, DEVELOPMENT THEREOF, AND COLLECTIONS OF CELLULAR REPORTERS
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机译:基因组学驱动的高速细胞测定,其发展以及细胞报告物的收集
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摘要
Methods for identifying responder genes and regulatory regions that confer responsiveness to a test substance or other perturbation are provided. Regulatory regions identified by such methods or other methods are cloned into expression constructs to control expression of a nucleic acid molecule that encodes, for example, a selectable marker or reporter, and introduced into cells. The resulting cells are used, for example, in high throughput screening assays for profiling substances and conditions and for studying the function of the regulatory region mediating the response. Addressable collections of the cells are also provided.
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