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LIPOSOMALLY ENCAPSULATED HYDROPHOBIC ACTIVE INGREDIENTS WITH A HIGH ACTIVE INGREDIENT CONTENT ⊃ 50 AND METHOD FOR THE PRODUCTION OF PHARMACEUTICAL PREPARATIONS CONTAINING LIPOSOMALLY ENCAPSULATED HYDROPHOBIC ACTIVE INGREDIENTS
LIPOSOMALLY ENCAPSULATED HYDROPHOBIC ACTIVE INGREDIENTS WITH A HIGH ACTIVE INGREDIENT CONTENT ⊃ 50 AND METHOD FOR THE PRODUCTION OF PHARMACEUTICAL PREPARATIONS CONTAINING LIPOSOMALLY ENCAPSULATED HYDROPHOBIC ACTIVE INGREDIENTS
The invention relates to liposomally encapsulated hydrophobic active ingredients, preferably liposomally encapsulated camptothecin or camptothecin analogs, said liposomes having a high active ingredient percentage of 50 %. The invention also relates to pharmaceutical compounds containing liposomally encapsulated hydrophic active ingredients, preferably liposomally encapsulated camptothecin or camptothecin analogs. Said preparations are produced by means of high-pressure homogenization, preferably with prior formation of a lipsomal gel wherein the active ingredient is diffused in a solution or produced with the formation of an aerosol.
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