Tryptophan analogs in proteins, peptides and peptidic structures

摘要

The invention relates to proteins, peptides and peptidic lead structures, which, due to the incorporation of tryptophan amino acid analogs, particularly chalcogen and / or halogen analogs, new crystallographic, spectral and / or pharmacological properties. Furthermore, the invention relates to a method for labeling proteins, peptides and peptide leads, in which these are provided by the incorporation of amino acid analogs with new crystallographic and / or spectral properties. Furthermore, the invention relates to a method for determining the three-dimensional structure of proteins, peptides or peptidic lead structures by means of crystal structure analysis. Finally, the invention relates to pharmaceutical compositions comprising as active ingredient at least a tryptophan analog which is incorporated into a carrier, such as a protein, a peptide, or a peptidic lead compound.