SUBSTITUTED 3-PYRIDYL PYRROLES AND 3-PYRIDYL PYRAZOLES AS C17,20 LYASE INHIBITORS

摘要

The invention provides novel substituted 3-pyridyl pyrroles and 3-pyridyl pyrazoles and pharmaceutical compositions thereof. The invention also provides methods of use of substituted 3-pyridyl pyrroles and 3-pyridyl pyrazoles and pharmaceutical compositions thereof as inhibitors of lyases, e.g., the 17α-hydroxylase-C17,20 enzyme. The invention further provides methods for the treatment of cancer in a subject, comprising administering a substituted 3-pyridyl pyrroles and 3-pyridyl pyrazoles or a pharmaceutical composition comprising a substituted 3-pyridyl pyrroles and 3-pyridyl pyrazoles to a subject. The cancer can be, e.g., prostate cancer or breast cancer.