BAG3 NUCLEOTIDE AND PROTEIN SEQUENCES TO BE USED IN RESEARCH, DIAGNOSTICS AND THERAPY FOR CELL DEATH-INVOLVING DISEASES

摘要

The present invention provides BAG3 nucleotide and protein sequences to be used in research, diagnostics and therapy for modulation of cell survival and/or death, in particular in leukemias, other neoplasias and apoptosis-involving diseases. More particularly the invention refers to the use of specific antisense­-based constructs and peptide-specific polyclonal and monoclonal antibodies in leukemias, other neoplasias and cell death- involving diseases.