TRANSGENIC MOUSE FOR SCREENING AND FOR STUDIES OF THE PHARMACODYNAMICS AND PHARMACOKINETICS OF LIGANDS ACTING ON INTRACELLULAR RECEPTORS, AND METHOD FOR THE PREPARATION THEREOF

摘要

Nonhuman transgenic mammal is prepared the purpose of the present invention is a kind of, can be used to monitor various tissues in vivo and activates the states of any intracellular receptor, can induce using reporter gene and which of natural or synthetic molecular activity these receptors is modulated by. Mammal is that problem is preferably mouse.