PURPOSE: A pharmaceutical composition containing a Rubiae Radix extract is provided. The composition has preventing and treating effects on ischemic stroke caused by damage of cerebral nerve cells and thus can be effectively used as a brain-protecting agent for treatment of brain damage. CONSTITUTION: A pharmaceutical composition contains a water extract and a methanol extract of Rubiae Radix and a fraction thereof as an active ingredient and a conventional pharmaceutically acceptable salt. The water extract of Rubiae Radix is a dried powder that is obtained by concentrating a Rubiae Radix extract prepared by any one method of a cold water precipitation, ultrasonic wave and refluxing, under reduced pressure, and then freeze drying. The composition is formulated into powders, granules, tablets, capsules, liquids and injections.
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