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A pharmaceutical composition having an abnormally altered drug metabolism and pharmacokinetic effects of correcting containing sulfur-containing acid Amano
A pharmaceutical composition having an abnormally altered drug metabolism and pharmacokinetic effects of correcting containing sulfur-containing acid Amano
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机译:含硫磺酸天野具有异常改变的药物代谢和纠正的药代动力学作用的药物组合物
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摘要
PURPOSE: The use of the amino acids containing a sulfur atom or their derivatives is provided, for revising the abnormal expression of drug metabolizing enzymes and the modified pharmaco dynamics. CONSTITUTION: The abnormal pharmaco-metabolism due to protein deficiency, tuberculosis, cancer, AIDS, fasting/starvation, diabetes or disorder in the digestive system, and thereby modified pharmaco dynamics are revised by administering the amino acids containing a sulfur atom or their derivatives such as cysteine, cystine, methionine, cysteate, N-acetylcysteine, homocysteine and homocysteate to humans or animals. The modified expressions of cytochrome P450, microsomal epoxide hydrolase (mEH) and glutathione S-transferase (GST) are normalized by the amino acids containing a sulfur atom or their derivatives. The revising effect is improved by administering the amino acids together with an antioxidizing agent such as vitamin C and vitamin E.
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