Pharmacokinetics, Metabolism and Pharmaceutics of Drugs of Abuse

摘要

;Contents: Introduction; The Potential Role of the Cytochrome P-450 2D6Pharmacogenetic Polymorphism in Drug Abuse; Human Liver Cocaine Carboxylesterases; Effects of Ethanol on Cocaine Metabolism and Disposition in the Rat; Individual Differences in Nicotine Kinetics and Metabolism in Humans; Inhibitors of Anandamide Breakdown; Metabolic Bioactivation Reactions Potentially Related to Drug Toxicities; The Role of Iminium-Enamine Species in the Toxication and Detoxication of Cyclic Tertiary Amines; Neurotoxicity of Amphetamines and Their Metabolites; Potential New Insights Into the Molecular Mechanisms of Methamphetamine-Induced Neurodegeneration; Immunotoxicology of Opioids, Inhalants, and Other Drugs of Abuse; Inhalation Studies With Drugs of Abuse; Biocatalysts in Detoxication of Drugs of Abuse; Antibodies as Pharmacokientic and Metabolic Modifiers of Neurotoxicity; Toxicokinetics in the National Toxicology Program.