Anti-inflammatory prenylated flavonoid derivatives and extract of Sophora flavescens therewith

摘要

PURPOSE: A prenylated flavonoid derivative extracted from Sophora flavescens and a new use of the Sophora flavescens extract and a methylene chloride fraction thereof as an antiinflammtory agent are provided. Therefore, they can be significantly used in chronic antiinflammtory diseases such as acute inflammation and rheumatic arthritis. CONSTITUTION: Sophora flavescens is extracted in one or two or more solvents selected from water, C1-4 lower alcohol, glycerol, propylene glycol, 1,3-butylene glycol, methylacetate, benzene, hexane, diethyl ether and methylene chloride, and the extract is suspended in distilled water and extracted in methylene chloride to produce a methylene fraction. An antiinflammtory agent contains a flavonoid derivative of formula 1 and a pharmaceutically acceptable salt thereof as an effective component. In formula, R1 is H or CH3; R2 is H or CH3; R3 is OH or OCH3 in which n is 0 to 3.