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Thiazol Ipanema encounter the inhibitor having a sol or oxazole structure, and a method of producing
Thiazol Ipanema encounter the inhibitor having a sol or oxazole structure, and a method of producing
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机译:噻唑依帕内玛遇到具有溶胶或恶唑结构的抑制剂及其生产方法
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摘要
PURPOSE: A novel compound having a superior anticancer effect is prepared. CONSTITUTION: The compounds of the formula (I) are manufactured and estimated for inhibiting activity of enzyme activity in K-Ras substrate. In the formula (I): X is O or S; A is H, lower alkyl, or one of formula (II) wherein, R1 is H, halogen, cyano, nitro and formula (III) wherein, R2 is H, lower alkyl, formyl, lower alkylcarbonyl, or aryl-substituted(unsubstituted) lower alkoxycarbonyl; B is one of formula (IV) and (V) wherein R3 and R4 are H, lower alkyl, lower alkoxy, halogen, cyano, hydroxy, phenyl or phenoxy, respectively; C is lower alkoxy or one of formula (VI) wherein, R5 and R6 are H, lower alkyl, aryl and the formula (VII) wherein, R7 is O or S.
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