Intermediates of Ipanema encounter the inhibitor has a pyrrole structure

摘要

PURPOSE: FTASE inhibitor intermediate having pyrrol structure intermediate is provided which has a good anticancer property. CONSTITUTION: FTase inhibitor intermediate is added in the obtained solution, and reacted at room temperature for 5 hours to give the compounds of formula 1, wherein A and D are H, phenyl or lower alkyl; B is phenyl or naphthyl; E is one of under the formulas; R1 and R2 are independently H or lower alkyl; Y is O, C=O, S=O or SO2. Thus, 234 mg of 3-hydroxycarbonyl-4-(naphthalen-1-yl)-1H-pyrrol is dissolved in 2 ml of dimethyl formamide, followed by addition of 230 mg of EDC, 101 mg of triethyl amine and 162 mg of HOBT, and stirred at 0C for 5 minutes. 124 Mg of N-(2-method ethyl)-N-methyl amine hydrochloride.