eliciting effect inhibiting OAC and to method of their synthesis and inhibitor of нOAC. Invention describes compounds of the general formula (1) where R1, R2, R3, R4 have similar or different values and taken among hydrogen atom, lower alkyl possibly substituted with halogen atom, phenyl possible substituted with halogen atom, lower alkyl, cyclic alkyl group with 3-8 carbon atoms; or R1 and R2 can in common form 3-8-membered ring; or R3 and R4 in common form monocyclic or condensed ring with 3-10 carbon atoms; X1, X2, X3, X4, X5, X6, X7, X8, X9 can be similar or different and taken among hydrogen atom and other values, respectively; A means substituted benzene or 5-6-membered aromatic heterocyclic ring possibly having substitutes; n and m each is a whole number = 0 or 1 under condition indicated in the invention claim or their possible tautomers, stereomers or optically active forms and pharmaceutically acceptable salt. Invention relates also to inhibitor of нOAC comprising the above indicated compounds and pharmaceutically acceptable carrier or diluting agent. Method of synthesis involves interaction of compound of the formula (2)
公开/公告号RU2193554C2
专利类型
公开/公告日2002-11-27
原文格式PDF
申请/专利号RU19990116598
申请日1997-12-24
分类号C07C215/56;C07C209/10;C07C217/92;C07C211/55;C07C323/09;C07C229/58;C07C229/60;C07D213/74;C07D213/80;C07D213/803;C07D213/82;C07D213/75;C07D213/78;C07D213/85;C07D207/42;C07D207/34;C07D241/16;C07D241/24;C07D237/24;C07D237/12;C07D237/20;C07D231/16;C07D231/14;A61K31/44;A61K31/137;A61K31/505;A61K31/40;A61K31/4965;A61K31/50;A61P9/10;
国家 RU
入库时间 2022-08-21 23:44:09