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POLYPEPTIDE DISPLAYING ANALOG OF RECEPTOR-BINDING EPIDERMAL GROWTH FACTOR FRAGMENT FROM 21 TO 31 AMINO ACIDS, ITS CONJUGATE WITH DOXORUBICIN AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF
POLYPEPTIDE DISPLAYING ANALOG OF RECEPTOR-BINDING EPIDERMAL GROWTH FACTOR FRAGMENT FROM 21 TO 31 AMINO ACIDS, ITS CONJUGATE WITH DOXORUBICIN AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF
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机译：多肽结合类表皮生长因子片段在21至31个氨基酸上的模拟显示，与阿霉素和基于其的药物组合物共轭
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摘要
FIELD: medicine, pharmacy. SUBSTANCE: invention relates to polypeptide that is analog of epidermal growth factor fragment from 21-31 amino acids as vector used for directed delivery of antitumor preparations in tumor cells. Invention proposes also conjugate of polypeptide with doxorubicin showing selective effect with respect to cancer tumors. Pharmaceutical composition comprises effective amount of conjugate and carrier useful for intravenous administration. EFFECT: enhanced effectiveness of preparation effect. 4 cl, 3 tbl, 2 dwg, 6 ex
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机译：领域：医学，药学。物质本发明涉及多肽，该多肽是来自21-31个氨基酸的表皮生长因子片段的类似物，作为用于在肿瘤细胞中定向递送抗肿瘤制剂的载体。本发明还提出了多肽与阿霉素的缀合物，其对癌症肿瘤具有选择性作用。药物组合物包含有效量的用于静脉内施用的缀合物和载体。效果：提高制备效果的有效性。 4 cl，3 tbl，2 dwg，6 ex
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