FRAGMENT ANALOG OF EPIDERMAL GROWTH FACTOR, CONJUGATE THEREOF CONTAINING DOXORUBICINE AND A PHARMACEUTICAL COMPOSITION BASED THEREON

摘要

The inventive biologically-active polypeptide of the formula MYIEALDSYAC is embodied in the form of a similar fragment of the epidermal growth factor of aminoacid ranging from 21 to 31 and capable of efficiently binding with the receptor of the epidermal growth factor as a vector for the directed supply of anticancer agents to tumour cells. The inventive conjugate of said polypeptide contains doxorubicine and has a selective action on cancer tumours and can substantially reduce the resistance of the tumour cells with respect to the anticancer agents, the conjugated parts of said agents being binded with the aid of a chemical bond which is unstable in relation to acid hydrolysis. The inventive pharmaceutical composition comprises an efficient quantity of conjugate and a carrier which is fit for intravenous injection. Said invention can be used for medicine for treating cancer patients.