GENE EXHIBITING DISEASE TYPE-SPECIFIC CHANGE IN EXPRESSION IN VARIOUS TYPES OF CANCER, AND UTILIZATION THEREOF

摘要

PROBLEM TO BE SOLVED: To provide a method for utilizing a gene specific to various types of cancer.;SOLUTION: Hybridization is carried out on slides obtained by preparing RNAs from 38 cell strains derived from lung cancer, 3 normal fibroblast strains, 43 clinical specimens of the lung cancer and 6 normal pulmonary tissues, labeling them with a fluorescent material, and immobilizing 7685 kinds of gene fragments thereon. Usual hierarchical clustering is applied thereto, and the whole cell strains and clinical specimens are separated to each different cluster. The gene expression profile influenced by each type of diseases is considered to be obtained by removing genes commonly highly expressing or lowly expressing in the cultured cell strains or the clinical specimens from the analysis, and a filtering method enabling the removal is newly considered and carried out. As a result, the gene exhibiting disease type-specific expression profile can be identified. The gene is considered to be useful in diagnosis and therapy of each type of the cancer.;COPYRIGHT: (C)2004,JPO