As for this invention, in the liquid phase, under existing of the water and uniform catalyst system, the methanol derivative whose methanol or carbonylation is possible making use of carbon monoxide to carbonyl the continual production method due to converting regards. Here, from the viewpoint that, temperature inside the reactor and acetic acid and/or it improves the production of methyl acetate, flow of the derivative whose methanol inside the reactor or carbonylation is possible, desirably with the multi variable predictive control devices, the carbon monoxide supply quantity, and reaction medium and/or among the parameters which decide the constitution in the air hole it is placed under one controlling at least.The Monsanto type and it can apply to the both manufacturing process of hydrous type the above-mentioned process low. Selective figure Figure 2
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