Crystal structures of P-selectin, P- and E-selectin complexes, and uses thereof

摘要

The present invention relates to the crystal and three dimensional structures of the lectin and EGF-like (LE) domains of P-selectin, the crystal and three dimensional structures of P-selectin LE and E-selectin LE each complexed with SLeX, as well as the crystal and three dimensional structure of P-selectin LE complexed with a functional PSGL-1 peptide modified by both tyrosine sulfation and SLeX. The present invention also provides methods for identifying agents which activate or inhibitor each of the foregoing structures. In addition, the present invention provides agents identified by such methods.