Use of the H3 histamine receptor gene involved in the regulation of food intake or body weight

摘要

In order to clarify the function of the histamine receptor H3 protein in vivo, an attempt was made to produce a non-human higher animal in which the expression of the histamine receptor H3 gene was artificially suppressed. As a result, it was found that the body weight, food intake, blood insulin level, or blood leptin level were increased in the non-human higher animals as compared with the control. Thus, it has been found that there is a link between abnormalities in the histamine receptor H3 protein and diseases characterized by changes in body weight or food intake, thereby screening for drugs for treating or preventing the disease, And the examination of the disease became possible.