Utilization of histamine receptor H3 gene involved in regulation of body weight or food intake

摘要

Drug compositions for the treatment and prevention of disorders of food intake and body weight contain as the active component histamine receptor H3 protein (I), or DNA encoding it, or an agonist or antagonist to it. Independent claims are also included for the following: (1) non-human higher animals in which the expression of (I) is artificially up or down-regulated; (2) cells from these animals; (3) screening methods for agonists and antagonists to (I), using as a marker: (i) modified binding of the test substance to (I); (ii) the level of expression of (I) in cells expressing it; and/or (iii) the level of expression of a reporter gene under the control of the transcription regulation region of the gene encoding (I); (4) modification of biological parameters in non-human higher animals in which the expression of (I) is artificially up or down-regulated; (5) and diagnostic reagents for disorders of food intake and body weight containing: (i) oligonucleotides (of at least 15 bases) hybridizing to the regulatory region of the gene encoding (I); or (ii) containing antibodies to (I). ACTIVITY : Anorectic. No biological data given. MECHANISM OF ACTION : Histamine receptor H3 (ant)agonist. No biological data given.