Treatment and prevention of arteriosclerosis, treatment and prevention of allergic reactions of the type Gel-Coombs type I, and treatment of skin diseases with follicular and epidermal hyperkeratosis and accelerated proliferation of keratinocytes Of enzyme inhibitor and its drug compound for drug and prevention

摘要

Combination of inhibitors of dipeptidyl peptidase IV (DP IV) and enzymes having the same substrate specificity (DP IV-analogous enzymatic activity) and inhibitors of alanyl aminopeptidase (aminopeptidase N, APN) and of enzymes having the same substrate specificity (APN-analogous enzymatic activity) for a more than additive to superadditive inhibition for the treatment of arteriosclerosis, for the treatment of allergic reactions of the type I according to the Gell and Coombs classification and for the treatment of dermatological diseases with follicular and epidermal hyperkeratoses and an enhanced proliferation of keratinocytes.