Method for screening substance for preventing or treating diseases associated with dysfunction of IL-6 family cytokine receptor

摘要

The present invention provides a method for screening a substance for preventing or treating a disease associated with dysfunction of an IL-6 family cytokine receptor, which comprises using a transgenic mouse expressing a gp130 mutant or a part thereof. The gp130 variant has a substitution or deletion of a tyrosine residue corresponding to the tyrosine residue at position 759 of the human gp130 protein, and / or one or more amino acid residues in a region containing the corresponding tyrosine residue. There is provided a screening method comprising substitution, insertion or deletion of a group.