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METHOD OF SCREENING SUBSTANCE FOR PREVENTING OR TREATING DISEASES IN ASSOCIATION WITH IL-6 FAMILY CYTOKINE RECEPTOR MALFUNCTION
METHOD OF SCREENING SUBSTANCE FOR PREVENTING OR TREATING DISEASES IN ASSOCIATION WITH IL-6 FAMILY CYTOKINE RECEPTOR MALFUNCTION
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机译:与IL-6家族细胞因子受体功能异常相关的预防或治疗疾病的筛查物质的方法
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摘要
The invention provides a method of screening for substances preventing or treating diseases in association with IL-6 family cytokine receptor malfunction, which comprises using a transgenic mouse or a part thereof expressing a gp130 variant, wherein said gp130 variant comprises a substitution or a deletion of a tyrosine residue, which corresponds to the tyrosine residue at position 759 of human gp130 protein, or a substitution, an insertion or a deletion of one or more amino acid residues in a region comprising said tyrosine residue.
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