Production manner null of nitrogen content aromatic hetero ring chemical compound

摘要

PURPOSE: To provide a new method for preparing the carboxamide of nitrogen- containing heterocyclic compound(N-heterocyclic compound) useful as an important intermediate for producing pharmaceuticals, which can be employed on an industrial scale. ;CONSTITUTION: The objective carboxamide of N-heterocyclic compound is obtained by reacting a N-heterocyclic compound with 3-35 moles, preferably 5-8 moles of formamide per mole of the N-heteroeyclic compound, in the presence of 1.1-3.0 moles of oxodisulfuric acid or its salt(preferably, ammonium salt) per mole of the N-heterocyclic compound at 20-80°C, preferably 65-75°C. It is preferable to carry out the reaction mentioned above in the presence of a strong acid in order to improve the selectivity in the carbamoylation. The carboxamide thus obtained is easily converted into a carboxylic acid of N- heterocyclic compound by hydrolysis.;COPYRIGHT: (C)1994,JPO