An image super resolution system computes a high resolution image of a target from multiple low resolution images of the same target. Each low resolution image differs slightly in perspective from each of the other low resolution images. A coarse registration operation determines initial estimates of registration parameters (e.g., representing shifts and rotation in perspective) associated with each low resolution image. A fine registration operation improves the initial estimates using Bayesian analysis to infer the registration parameters and an acuity parameter. As such, a marginal likelihood of the low resolution images is optimized to determine the improved estimates of the registration parameters and the acuity parameter, which are used to solve for the high resolution image.
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