Methods for diagnosing individuals with an increased risk to develop a deficiency based on mdr1 gene polymorphism

摘要

The present invention relates to in vitro methods of diagnosing an increased risk to develop a renal, liver or colon deficiency, a deficiency in lymphoid cells or a deficiency at the blood brain barrier. Furthermore, the present invention also relates to the use of a MDR-1 gene single nucleotide polymorphism for the preparation of a diagnostic composition for diagnosing a renal, liver or colon deficiency, a deficiency in lymphoid cells or a deficiency at the blood brain barrier. Preferably, the renal, liver or colon deficiencies, the deficiency in lymphoid cells or the deficiencies at the blood brain barrier are caused by cancer.