Benzodiazepine inhibitors of mitochondial F1F0 ATP hydrolase and methods of inhibiting F1F0 ATP hydrolase

摘要

Compounds having the formula (I), chemistry chemdraw filechemistry mol file;are useful as inhibitors of mitochondrial F₁F₀ ATP hydrolase, wherein R₁, R₅ and R₇ are optional substituents, R₂, R₃ and R₄ are hydrogen, alkyl, or substituted alkyl, or comprise a bond to R, T or Y; Z and Y are selected from C(O), CO₂, SO₂, CH₂, CH₂C(O), and C(O)C(O), or Z may be absent; R and T are CH₂, C(O), or CH(CH₂)_p(Q), wherein Q is NR₁₀R₁₁, OR₁₀ or CN and p is 0, 1 or 2; R₆ is alkyl, alkenyl, substituted alkyl, substituted alkenyl, aryl, cycloalkyl, heterocyclo, or heteroaryl; R₁₀ and R₁₁ are hydrogen, alkyl, or substituted alkyl; and r and t are 0 or 1.