Oxidoreductase gene associated with the fra16d fragile site

摘要

The FRA16D fragile site is shown to be located within a gene encoding a protein termed FOR. The fragile site is the location of breakpoints of a variety of chromosomal rearrangements and other mutations associated with tumour cell lines. The FOR protein is shown to be expressed as a number of splice variants. The coding region of the gene encoding FOR protein has been DNA sequenced as has the FRA16D fragile sites. Protein interactive WW domains have been identified as has an oxidoreductase domain. This invention provides for certain diagnostic and potential therapeutic benefits.