Substituted 3amp;prime;,4amp;prime;-di-O-camphanoyl-(amp;plus;)-cis-khellactone analogs, compositions thereof, and methods for using thereof

摘要

3′,4′-di-O-camphanoyl-(+)-cis-khellactone analogs according to the present invention have been found to have anti-HIV activity. The compounds of the present invention have the following formula: ;or a pharmaceutically acceptable salt, ester or prodrug thereof, wherein R¹, R², R³, R⁴, X, and Z are set in the specification. The invention is also directed to pharmaceuticals compositions comprising one or more compounds of Formula I, optionally further comprising one or more anti-viral agents or immunostimulating agents. Further, the invention is directed to the use of compounds of Formula I for the inhibition of a retroviral infection in cells or tissue of an animal, for the treatment of a patient suffering from a retroviral-related pathology, for the prevention of transmission of HIV infection from an HIV infected pregnant woman to a fetus, and for the prevention of transmission of HIV infection during sexual intercourse.