METHOD FOR PRODUCTION OF 1,2,3,6-TETRAHYDRONICOINIC ACID AND 1-(4amp;prime;-METHOXYPHENACYL)-3-ETHOXYCARBONYL PYRIDINIUM BROMIDE OR 1-(3amp;prime;,4amp;prime;-DIMETHOXYPHENACYL)-3-ETHOXYCARBONYL PYRIDINIUM BROMIDE AS INTERMEDIATE PRODUCTS FOR ITS PRODUCTION

摘要

FIELD: organic chemistry. SUBSTANCE: 1-(4′-methoxyphenacyl)-3-ethoxycarbonyl pyridinium bromide or 1-(3',4′-dimethoxyphenacyl)-3-ethoxycarbonyl pyridinium bromide having common formula where R is H or OCH₃ are prepared by interaction of 1-(4′-methoxyphenacyl)- or 1-(3′,4′, 4-dimethoxyphenacyl)-3-ethoxycarbonyl pyridinium bromide with sodium boron hydride which takes place in aqueous-methanol medium, then interaction with concentrated hydrogen chloride acid is carried out. EFFECT: increased yield, simplified technology for its production.