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Fusion protein and its use in an immunoassay for the simultaneous detection of autoantibodies related to insulin-dependent diabetes mellitus
Fusion protein and its use in an immunoassay for the simultaneous detection of autoantibodies related to insulin-dependent diabetes mellitus
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机译:融合蛋白及其在免疫检测中用于同时检测与胰岛素依赖型糖尿病有关的自身抗体的用途
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摘要
The invention relates to a fusion protein having epitopes of at least two of the autoantigens glutamic acid decarboxylase (GAD65), islet cell antigen (IA2) and preproinsulin (PPINS) wherenin said epitopes are connected with a linker peptide. The fusion protein must be able to bind to a solid phase.;The invention also concerns the cDNA, and a vector and cell comprising said cDNA. Furthermore, this invention relates to the use of said fusion protein in an immunoassay for the simultaneous detection of autoantibodies related to insulin-dependent diabetes mellitus.
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